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# Select Publications
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An assortment of scientific articles authored or co-authored by team members, covering RWE in ALS and other disease areas.
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## Publications
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## 2025
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- Nature Medicine biomarker consortium (citation in original).
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- IJERPH: LASSO regression paper.
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- Pediatric Research: LLMs and clinical calculations.
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### Big data research is everyone’s research—Making epilepsy data science accessible to the global community: Report of the ILAE Big Data Commission
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**Josephson, C. B., Aronica, E., Beniczky, S., Boyce, D., Cavalleri, G., Denaxas, S., French, J., Jehi, L., Koh, H., Kwan, P., McDonald, C., Mitchell, J. W., Rampp, S., Sadleir, L., Sisodiya, S. M., Wang, I., Wiebe, S., Yasuda, C., Youngerman, B.** (2024). *Epileptic Disorders*.
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## 2024
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- Wearables and ALS progression (JNER).
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- ILAE Big Data Commission (Epilepsia Open).
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- CDC ALS registry qualitative risk factor analysis (ALS & FTD).
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A comprehensive review by the ILAE Big Data Commission aimed at demystifying how clinicians and researchers can engage with Big Data—including clinical, imaging, EEG, and common data models—in epilepsy research and care. It addresses practical, ethical, and equity-related challenges while showcasing the transformative potential of advanced data science methods.
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## 2023
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- Wearables and ML preprint (medRxiv).
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📖 [Read the article](https://doi.org/10.1002/epd2.20288)
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### Identification of patients with drug-resistant epilepsy in electronic medical record data using the Observational Medical Outcomes Partnership Common Data Model
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**Castano, V. G.** *et al.* (2022). A study leveraging the OMOP Common Data Model to identify patients with drug-resistant epilepsy using EMR data. Demonstrates phenotype identification using standardized data structures.
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📖 [PubMed link](https://pubmed.ncbi.nlm.nih.gov/36106377/)
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### Patient characteristics and antiseizure medication pathways in newly diagnosed epilepsy: Feasibility and pilot results using the common data model in a single-center electronic medical record database
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**Spotnitz, M.** *et al.* (2022). A pilot demonstrating feasibility of characterizing adult epilepsy patients and their antiseizure medication treatment pathways using CDM in an EHR-derived dataset.
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📖 [PubMed link](https://pubmed.ncbi.nlm.nih.gov/35276502/)
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### Characterization of Anti-seizure Medication Treatment Pathways in Pediatric Epilepsy Using the Electronic Health Record-Based Common Data Model
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**Kim, H.** *et al.* (2020). Analyzes pediatric epilepsy antiseizure medication treatment pathways using the OMOP CDM based on EHR data. Supports feasibility and applicability of CDM for pediatric epilepsy research.
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📖 [PubMed link](https://pubmed.ncbi.nlm.nih.gov/32477256/)
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## 2022
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- npj Digital Medicine ALS severity measure.

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