Solenoid Analyses

Analyses for multi-unit spiking responses & evoked local field potentials (LFP) obtained in response to mechanical stimulation of the forelimb digits ("Solenoid"), intracortical microstimulation (ICMS), or Solenoid+ICMS stimuli from the anesthetized rat.

• Start with main.m
• Organization of objects is hierarchical:
  • solBlock is "child" to solRat
  • solChannel is "child" to solBlock
  • Constructor for solRat automatically generates all subordinate solBlock and solChannel objects, so the main access-point in general for batch analysis is solRat, while methods at solBlock level are more for trouble-shooting and testing or development.
• Once all solRat objects are constructed, they can be saved using the overloaded save method of solRat.
• Once batch figures are exported (also requires connection to KUMC Isilon Processed_Data drives), the exported figures can be viewed using the figBrowser class, which is primarily convenient if you need to re-export higher resolution versions of existing figures.

To-Do

• Determine if there is usable data to test the following generic hypothesis:
  • ICMS induces functional changes in somatosensory evoked potentials.
• To test this hypothesis, we should examine these sub-hypotheses:
  • ICMS induces a statistically significant change in duration between first evoked multi-unit spike peak and cutaneous stimulus offset, compared to responses during cutaneous stimulation only.
  • ICMS induces a statistically significant change in magnitude of average evoked LFP response when paired with cutaneous stimuli.
• To bring these hypotheses into clinical relevance, we should test the following hypotheses:
  • ICMS in RFA (which is where most of the stimuli were targeted) alters evoked responses (spiking, LFP, or linear/nonlinear metrics of information transfer between the two areas in response to cutaneous stimulus) in FL-S1.