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.zenodo.json

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{
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"title": "Tri-Modal Antifungal Catheter Lock (TCL): Open Proof of Invention",
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"upload_type": "dataset",
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"description": "LaTeX sources, figures, and compiled PDF for the public disclosure of the Tri-Modal Catheter Lock (TCL) addressing Candida auris biofilms. Includes workflow schematics and manufacturing/spec documentation for reproducibility.",
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"title": "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record",
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"upload_type": "publication",
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"publication_type": "technicalnote",
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"description": "<p>This repository provides the open scientific disclosure and LaTeX documentation for the <b>Tri-Modal Antifungal Catheter Lock (TCL)</b> — a novel, non-systemic antifungal catheter lock composition designed to eradicate <i>Candidozyma (Candida) auris</i> and other resistant fungal biofilms. The TCL integrates three synergistic mechanisms: (1) echinocandin antifungal activity, (2) β-1,3-glucanase enzymatic digestion of the extracellular matrix, and (3) gallium(III)/EDTA-mediated iron substitution disrupting metabolic integrity. Together, these effects yield ≥3-log biofilm reduction within 90 minutes without catheter degradation.</p>",
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"creators": [
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{
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"name": "Valamontes, Antonios",
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"affiliation": "Kapodistrian Academy of Science",
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"orcid": "0009-0008-5616-7746"
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},
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{
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"name": "Adamopoulos, Ioannis",
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"affiliation": "Public Health and Environmental Inspector, Department of Environmental Hygiene and Public Health Inspections, Region of Attica, Hellenic Republic"
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}
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],
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"contributors": [
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{
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"name": "Kapodistrian Academy of Science",
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"type": "HostingInstitution"
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}
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],
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"keywords": [
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"Candida auris",
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"biofilm",
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"catheter lock",
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"echinocandin",
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"beta-1,3-glucanase",
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"β-1,3-glucanase",
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"gallium",
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"EDTA",
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"CRISPR Cas12",
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"public health",
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"infection control"
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"infection control",
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"public health"
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],
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"language": "eng",
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"license": "cc-by-nc-4.0",
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"related_identifiers": [],
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"notes": "Non-commercial research use only. Commercial licensing requests: [email protected]."
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"communities": [],
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"access_right": "open",
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"language": "eng"
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"related_identifiers": [
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{
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"relation": "isSupplementTo",
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"identifier": "https://github.com/Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL"
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}
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],
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"notes": "This proof-of-invention disclosure establishes timestamped prior-art protection. Commercial manufacturing or distribution of TCL formulations requires explicit written licensing from the inventor. Contact [email protected] for licensing inquiries.",
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"grants": [],
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"communities": [
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{
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"identifier": "open-science"
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}
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],
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"upload_type_terms": "software, dataset, publication",
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"version": "1.0.0",
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"doi": "",
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"publication_date": "2025-11-12"
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}
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