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1 | 1 | { |
2 | | - "title": "Tri-Modal Antifungal Catheter Lock (TCL): Open Proof of Invention", |
3 | | - "upload_type": "dataset", |
4 | | - "description": "LaTeX sources, figures, and compiled PDF for the public disclosure of the Tri-Modal Catheter Lock (TCL) addressing Candida auris biofilms. Includes workflow schematics and manufacturing/spec documentation for reproducibility.", |
| 2 | + "title": "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record", |
| 3 | + "upload_type": "publication", |
| 4 | + "publication_type": "technicalnote", |
| 5 | + "description": "<p>This repository provides the open scientific disclosure and LaTeX documentation for the <b>Tri-Modal Antifungal Catheter Lock (TCL)</b> — a novel, non-systemic antifungal catheter lock composition designed to eradicate <i>Candidozyma (Candida) auris</i> and other resistant fungal biofilms. The TCL integrates three synergistic mechanisms: (1) echinocandin antifungal activity, (2) β-1,3-glucanase enzymatic digestion of the extracellular matrix, and (3) gallium(III)/EDTA-mediated iron substitution disrupting metabolic integrity. Together, these effects yield ≥3-log biofilm reduction within 90 minutes without catheter degradation.</p>", |
5 | 6 | "creators": [ |
6 | 7 | { |
7 | 8 | "name": "Valamontes, Antonios", |
8 | 9 | "affiliation": "Kapodistrian Academy of Science", |
9 | 10 | "orcid": "0009-0008-5616-7746" |
| 11 | + }, |
| 12 | + { |
| 13 | + "name": "Adamopoulos, Ioannis", |
| 14 | + "affiliation": "Public Health and Environmental Inspector, Department of Environmental Hygiene and Public Health Inspections, Region of Attica, Hellenic Republic" |
| 15 | + } |
| 16 | + ], |
| 17 | + "contributors": [ |
| 18 | + { |
| 19 | + "name": "Kapodistrian Academy of Science", |
| 20 | + "type": "HostingInstitution" |
10 | 21 | } |
11 | 22 | ], |
12 | 23 | "keywords": [ |
13 | 24 | "Candida auris", |
| 25 | + "biofilm", |
14 | 26 | "catheter lock", |
15 | 27 | "echinocandin", |
16 | | - "beta-1,3-glucanase", |
| 28 | + "β-1,3-glucanase", |
17 | 29 | "gallium", |
18 | 30 | "EDTA", |
19 | | - "CRISPR Cas12", |
20 | | - "public health", |
21 | | - "infection control" |
| 31 | + "infection control", |
| 32 | + "public health" |
22 | 33 | ], |
| 34 | + "language": "eng", |
23 | 35 | "license": "cc-by-nc-4.0", |
24 | | - "related_identifiers": [], |
25 | | - "notes": "Non-commercial research use only. Commercial licensing requests: [email protected]." |
26 | | - "communities": [], |
27 | 36 | "access_right": "open", |
28 | | - "language": "eng" |
| 37 | + "related_identifiers": [ |
| 38 | + { |
| 39 | + "relation": "isSupplementTo", |
| 40 | + "identifier": "https://github.com/Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL" |
| 41 | + } |
| 42 | + ], |
| 43 | + "notes": "This proof-of-invention disclosure establishes timestamped prior-art protection. Commercial manufacturing or distribution of TCL formulations requires explicit written licensing from the inventor. Contact [email protected] for licensing inquiries.", |
| 44 | + "grants": [], |
| 45 | + "communities": [ |
| 46 | + { |
| 47 | + "identifier": "open-science" |
| 48 | + } |
| 49 | + ], |
| 50 | + "upload_type_terms": "software, dataset, publication", |
| 51 | + "version": "1.0.0", |
| 52 | + "doi": "", |
| 53 | + "publication_date": "2025-11-12" |
29 | 54 | } |
| 55 | + |
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