|
1 | | -cff-version: 1.2.0 |
2 | | -message: "If you use this work, please cite it as below." |
3 | | -title: "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record" |
4 | | -version: "1.0.0" |
5 | | -doi: "10.5281/zenodo.XXXXXXX" |
6 | | -date-released: "2025-11-12" |
7 | | - |
8 | | -authors: |
9 | | - - family-names: "Valamontes" |
10 | | - given-names: "Antonios" |
11 | | - affiliation: "Kapodistrian Academy of Science" |
12 | | - |
13 | | - orcid: "https://orcid.org/0009-0008-5616-7746" |
14 | | - - family-names: "Adamopoulos" |
15 | | - given-names: "Ioannis" |
16 | | - affiliation: "Public Health and Environmental Inspector, Department of Environmental Hygiene and Public Health Inspections, Region of Attica, Hellenic Republic" |
17 | | - |
18 | | -abstract: > |
19 | | - This record discloses the Tri-Modal Antifungal Catheter Lock (TCL), |
20 | | - a non-systemic antifungal formulation combining three synergistic mechanisms: |
21 | | - (1) echinocandin antifungal inhibition of β-glucan synthase, |
22 | | - (2) β-1,3-glucanase enzymatic digestion of extracellular matrix polysaccharides, |
23 | | - and (3) gallium(III)/EDTA complex-induced iron substitution disrupting |
24 | | - metabolic integrity of fungal biofilms. Together, these interactions produce |
25 | | - ≥3-log biofilm reduction within 90 minutes without catheter degradation. |
26 | | - The proof of invention establishes timestamped prior-art protection |
27 | | - for open scientific disclosure and non-commercial research collaboration. |
28 | | - |
29 | | -keywords: |
30 | | - - Candida auris |
31 | | - - biofilm |
32 | | - - catheter lock |
33 | | - - echinocandin |
34 | | - - β-1,3-glucanase |
35 | | - - gallium |
36 | | - - EDTA |
37 | | - - infection control |
38 | | - - public health |
39 | | - |
40 | | -repository-code: "https://github.com/Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL" |
41 | | -license: "CC-BY-NC-4.0" |
42 | | -license-url: "https://creativecommons.org/licenses/by-nc/4.0/" |
43 | | -type: "software" |
44 | | - |
45 | | -preferred-citation: |
46 | | - type: article |
47 | | - authors: |
48 | | - - family-names: "Valamontes" |
49 | | - given-names: "Antonios" |
50 | | - - family-names: "Adamopoulos" |
51 | | - given-names: "Ioannis" |
52 | | - title: "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record" |
53 | | - journal: "Kapodistrian Academy of Science" |
54 | | - year: 2025 |
55 | | - doi: "10.5281/zenodo.XXXXXXX" |
56 | | - url: "https://doi.org/10.5281/zenodo.XXXXXXX" |
57 | | - |
58 | | - |
| 1 | +{ |
| 2 | + "title": "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record", |
| 3 | + "upload_type": "publication", |
| 4 | + "publication_type": "report", |
| 5 | + "description": "<p>Open scientific disclosure and LaTeX documentation for the <b>Tri-Modal Antifungal Catheter Lock (TCL)</b> — a non-systemic antifungal catheter lock combining three synergistic mechanisms: (1) echinocandin inhibition of β-glucan synthase, (2) β-1,3-glucanase enzymatic digestion of the extracellular matrix, and (3) gallium(III)/EDTA complex-induced iron substitution disrupting fungal metabolic integrity. Together, these mechanisms produce ≥3-log biofilm reduction within 90 minutes without catheter degradation.</p>", |
| 6 | + "creators": [ |
| 7 | + { |
| 8 | + "name": "Valamontes, Antonios", |
| 9 | + "affiliation": "Kapodistrian Academy of Science", |
| 10 | + "orcid": "0009-0008-5616-7746" |
| 11 | + }, |
| 12 | + { |
| 13 | + "name": "Adamopoulos, Ioannis", |
| 14 | + "affiliation": "Public Health and Environmental Inspector, Department of Environmental Hygiene and Public Health Inspections, Region of Attica, Hellenic Republic" |
| 15 | + } |
| 16 | + ], |
| 17 | + "keywords": [ |
| 18 | + "Candida auris", |
| 19 | + "biofilm", |
| 20 | + "catheter lock", |
| 21 | + "echinocandin", |
| 22 | + "β-1,3-glucanase", |
| 23 | + "gallium", |
| 24 | + "EDTA", |
| 25 | + "infection control", |
| 26 | + "public health" |
| 27 | + ], |
| 28 | + "language": "eng", |
| 29 | + "license": "cc-by-nc-4.0", |
| 30 | + "access_right": "open", |
| 31 | + "related_identifiers": [ |
| 32 | + { |
| 33 | + "relation": "isSupplementTo", |
| 34 | + "identifier": "https://github.com/Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL", |
| 35 | + "scheme": "url" |
| 36 | + } |
| 37 | + ], |
| 38 | + "notes": "This record constitutes timestamped prior-art disclosure for open scientific collaboration. Commercial manufacturing or distribution of TCL formulations requires prior written authorization. Contact [email protected] for licensing inquiries.", |
| 39 | + "version": "1.0.0", |
| 40 | + "publication_date": "2025-11-12" |
| 41 | +} |
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