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Circadian-Subtypes-Breast-Cancer-Cells

Analysis code for:

Ector C, Didier J, De Landtsheer S, Nordentoft MS, Schmal C, Keilholz U, Herzel H, Kramer A, Sauter T, Granada AE. Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity. Molecular Systems Biology 2025;21:315. DOI: 10.1038/s44320-025-00092-7

Contents

Folder Description
Figure2_deep_circadian_phenotyping Deep circadian phenotyping pipeline and classification
Figure3_and_Figure4_pipelines Subtype analysis and comparison pipelines
Figure4_drug_sensitivity_parameter_calculation Drug sensitivity metrics and parameter extraction

Requirements

  • Python 3.8 or later
  • numpy, scipy, pandas, matplotlib, seaborn
  • pyBOAT for time-frequency analysis of circadian traces

License

MIT — see LICENSE. This code was developed by members and collaborators of the Granada Lab research group. For authorship and correspondence, please refer to the publication above.