drivers_ToD_drug_sensitivity

Analysis code for:

Gutu N, Ishikuma H, Ector C, Keilholz U, Herzel H, Granada AE. A combined mathematical and experimental approach reveals the drivers of time-of-day drug sensitivity in human cells. Communications Biology 2025;8:491. DOI: 10.1038/s42003-025-07931-1

Contents

Code is organised by figure panels:

Folder	Figures
Fig2	Figure 2
Fig3	Figure 3
Fig4	Figure 4
Fig5	Figure 5

Requirements

• Python 3.8 or later: numpy, matplotlib, scipy, pandas, seaborn, pyboat
• MATLAB R2021b or later (Statistics and Machine Learning Toolbox, Simulink, Bioinformatics Toolbox)

License

MIT — see LICENSE. This code was developed by members and collaborators of the Granada Lab research group. For authorship and correspondence, please refer to the publication above.