fix q2 formula according to paper. recalculate rate constants after applying the opiates correction. #247
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…pplying the opiates correction.
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In the paper, as well as in the NONMEM code, age maturation is not divided by reference age maturation for calculation of Q2.
The with_opiates() function calls from_clearances() which will recalculate the rate constants, but not transform them from min-1 to s-1 like setup() does.