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[2024 Nature Methods] Assessing GPT-4 for cell type annotation in single-cell RNA-seq analysis[paper]
[2024 biorxiv] Metric Mirages in Cell Embeddings[paper]
[2023 biorxiv] A Deep Dive into Single-Cell RNA Sequencing Foundation Models[paper]
[2023 bioRxiv scEval] Evaluating the Utilities of Large Language Models in Single-cell Data Analysis[paper]
[2023 bioRxiv] Assessing the limits of zero-shot foundation models in single-cell biology[paper]
[2023 bioRxiv] Foundation Models Meet Imbalanced Single-Cell Data When Learning Cell Type Annotations[paper]
[2023 bioRxiv] Evaluation of large language models for discovery of gene set function[paper]
[2024 ICLR benchmark DNA FD] BEND: Benchmarking DNA Language Models on Biologically Meaningful Tasks[paper]
Foundation-Model-For-Single-cell
[2024 BioRxiv] Multimodal learning of transcriptomes and text enables interactive single-cell RNA-seq data exploration with natural-language chats [paper]
[2024 BioRxiv] CancerFoundation: A single-cell RNA sequencing foundation model to decipher drug resistance in cancer [paper]
[2024 BioRxiv] scChat: A Large Language Model-Powered Co-Pilot for Contextualized Single-Cell RNA Sequencing Analysis [paper]
[2024 BioRxiv] Cell-ontology guided transcriptome foundation model [paper]
[2024 BioRxiv] How to Build the Virtual Cell with Artificial Intelligence: Priorities and Opportunities [paper]
[2024 Nature Methods] Transformers in single-cell omics: a review and new perspectives [paper]
[2024 BioRxiv] Cell-Graph Compass: Modeling Single Cells with Graph Structure Foundation Model [paper]
[2024 BioRxiv] scPRINT: pre-training on 50 million cells allows robust gene network predictions [paper]
[2024 biorxiv] Precious3GPT: Multimodal Multi-Species Multi-Omics Multi-Tissue Transformer for Aging Research and Drug Discovery[paper]
[2024 biorxiv] scMulan: a multitask generative pre-trained language model for single-cell analysis[paper]
[2024 biorxiv] CELLama: Foundation Model for Single Cell and Spatial Transcriptomics by Cell Embedding Leveraging Language Model Abilities[paper]
[2024 biorxiv] LangCell: Language-Cell Pre-training for Cell Identity Understanding[paper]
[2024 biorxiv] Nicheformer: a foundation model for single-cell and spatial omics[paper]
[2024 biorxiv] Large-scale characterization of cell niches in spatial atlases using bio-inspired graph learning[paper]
[2024 biorxiv] scmFormer Integrates Large-Scale Single-Cell Proteomics and Transcriptomics Data by Multi-Task Transformer[paper]
[2024 biorxiv] Sequence modeling and design from molecular to genome scale with Evo[paper]
[2023 Nature Machine Intelligence] Reusability report: Learning the transcriptional grammar in single-cell RNA-sequencing data using transformers[paper]
[2023 bioRxiv] Scalable querying of human cell atlases via a foundational model reveals commonalities across fibrosis-associated macrophages[paper]
[2023 bioRxiv] To Transformers and Beyond: Large Language Models for the Genome[paper]
[2023 bioRxiv] A pre-trained large generative model for translating single-cell transcriptome to proteome[paper]
[2023 bioRxiv] GENEPT: A SIMPLE BUT HARD-TO-BEAT FOUNDATION MODEL FOR GENES AND CELLS BUILT FROM CHATGPT[paper]
[2023 bioRxiv] CellPLM: Pre-training of Cell Language Model Beyond Single Cells[paper]
[2023 Nature Biotechnology multi-modal] Integration of multi-modal single-cell data[Paper]
[2023 bioRxiv multi-modal] Single-cell gene expression prediction from DNA sequence at large contexts[paper]
[2023 bioRxiv multi-modal] Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation[paper]
[2023 bioRxiv] CellPolaris: Decoding Cell Fate through Generalization Transfer Learning of Gene Regulatory Networks[paper]
[2023 bioRxiv] GeneCompass: Deciphering Universal Gene Regulatory Mechanisms with Knowledge-Informed Cross-Species Foundation Model[paper]
[2023 bioRxiv] scHyena: Foundation Model for Full-Length Single-Cell RNA-Seq Analysis in Brain[paper]
[2023 XXXX] A Deeper Dive into Single-Cell RNA Sequencing Foundation Models
[2023 bioRxiv] GET: a foundation model of transcription across human cell types[paper]
[2024 ICML] Cell2Sentence: Teaching Large Language Models the Language of Biology[paper]
[2023 bioRxiv][scTranslator] A pre-trained large language model for translating single-cell transcriptome to proteome[paper]
[2023 bioRxiv][scPoli] Population-level integration of single-cell datasets enables multi-scale analysis across samples[paper]
[2023 bioRxiv] Towards Universal Cell Embeddings: Integrating Single-cell RNA-seq Datasets across Species with SATURN[paper]
[2023 bioRxiv][scFoundation] Large Scale Foundation Model on Single-cell Transcriptomics[paper]
[2023 Nature][GeneFormer] Transfer learning enables predictions in network biology[paper]
[2023 iSchience][tGPT] Generative pretraining from large-scale transcriptomes for single-cell deciphering[paper]
[2023 bioRxiv][scGPT] scGPT: Towards Building a Foundation Model for Single-Cell Multi-omics Using Generative AI[paper v1], [paper v2]
[2023 bioRxiv][xTrimoGene] xTrimoGene: An Efficient and Scalable Representation Learner for Single-Cell RNA-Seq Data[paper]
[2022 arxiv][Exceiver] A single-cell gene expression language model[paper]
[2022 Nature Machine Intelligence][scBERT] scBERT as a large-scale pretrained deep language model for cell type annotation of single-cell RNA-seq data[paper]
[2022 bioRxiv][scFormer] scFormer: a universal representation learning approach for single-cell data using transformers[paper]
[2022 Bioinformatics][scPretrain] scPretrain: multi-task self-supervised learning for cell-type classification[paper]
Foundation-Model-Genetic-Perturbation
[2024 biorxiv] Benchmarking a foundational cell model for post-perturbation RNAseq prediction[paper]
[2024 biorxiv] Benchmarking Transcriptomics Foundation Models for Perturbation Analysis: one PCA still rules them all[paper]
[2024 biorxiv] PertEval-scFM: Benchmarking Single-Cell Foundation Models for Perturbation Effect Prediction[paper]
[2024 BioRxiv] scGenePT: Is language all you need for modeling single-cell perturbations? [paper]
[2024 Cell, FM4perturbation data: a review] Toward a foundation model of causal cell and tissue biology with a Perturbation Cell and Tissue Atlas [paper]
[2023 NM] Causal identification of single-cell experimental perturbation effects with CINEMA-OT[paper]
Foundation-Model-For-Pathology
[2024 bioRxiv] BiomedParse: a biomedical foundation model for image parsing of everything everywhere all at once[paper]
[2024 Nature] A whole-slide foundation model for digital pathology from real-world data[paper]
[2024 Nature Medicine FM4Pathology] Towards a general-purpose foundation model for computational pathology[paper]
[2024 Nature Medicine FM4Pathology] A visual-language foundation model for computational pathology[paper]
[2023 Nature Medicine] A visual–language foundation model for pathology image analysis using medical Twitter[paper]
Foundation-Model-For-DNA
[2024 bioRxiv] CpGPT: a Foundation Model for DNA Methylation[paper]
[2024 bioRxiv] Evaluating the representational power of pre-trained DNA language models for regulatory genomics[paper]