Version 12.1

[Yuri05]

Description

Merge develop ➡️ master before release.

Type of change

Please mark relevant options with an x in the brackets.

• Bug fix (non-breaking change which fixes an issue)
• New feature (non-breaking change which adds functionality)
• Breaking change (fix or feature that would cause existing functionality to not work as expected)
• This change requires documentation changes (link at least one user or developer documentation issue):
• Algorithm update - updates algorithm documentation/questions/answers etc.
• Other (please describe): Merge develop ➡️ master before release.

How Has This Been Tested?

Please describe the tests that you ran to verify your changes. Provide instructions so we can reproduce. Please also list any relevant details for your test configuration

• Integration tests
• Unit tests
• Manual tests
• No tests required

Reviewer checklist

Mark everything that needs to be checked before merging the PR.

• Check if the code is well documented
• Check if the behavior is what is expected
• Check if the code is well tested
• Check if the code is readable and well formatted
• Additional checks (document below if any)
• Check if documentation update issue(s) are created if the option This change requires a documentation update above is selected

Screenshots (if appropriate):

Questions (if appropriate):

[Copilot]

Pull Request Overview

This PR prepares version 12.1 for release by merging the develop branch to master. The changes encompass significant dependency updates, enhanced simulation management features, and improvements to code organization and configuration.

• Major version upgrade from 12.0 to 12.1 with comprehensive NuGet package updates
• Enhanced simulation execution management with improved cancellation and status tracking
• Code modernization including CI/CD migration from AppVeyor to GitHub Actions

Reviewed Changes

Copilot reviewed 134 out of 137 changed files in this pull request and generated no comments.

Show a summary per file

File	Description
PKSim.sln	Added GitHub Actions workflow configurations
tests/**/*.csproj	Updated NuGet package versions and added version configuration
src/**/*.csproj	Updated to version 12.1.0 and upgraded dependencies
src/PKSim.Presentation/UICommands/StopSimulationCommand.cs	Changed from IUICommand to ActiveObjectUICommand with simulation-specific stopping
src/PKSim.Core/Services/InteractiveSimulationRunner.cs	Added concurrent simulation management and cancellation support
src/PKSim.Core/Services/SimulationRunner.cs	Added CancellationToken support to simulation execution
appveyor*.yml	Removed AppVeyor configuration files
.github/workflows/*.yml	Added GitHub Actions workflows for build, test, and deployment

Files not reviewed (1)

• src/PKSim.Assets.Images/Images.Designer.cs: Language not supported

---

_{Tip: Customize your code reviews with copilot-instructions.md. Create the file or learn how to get started.}