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Jasmin Aschenbrenner edited this page Aug 6, 2024 · 1 revision

Repurposing toolbox compounds targeting the SARS-CoV-2 nsp3 macrodomain

Background

Rules of Participation

The Story So Far

Origins of this Project

What is Known

Crystallographic Fragment Screen of CHIKV nsP3 macrodomain

Construct and Protein Production

Crystallisation of CHIKV nsP3 macrodomain

Fragment Screen and Data Analysis

Fragment Progression

Fast Forward Fragment Approach

Algorithmic Fragment Elaboration

Catalogue Compounds

Other Approaches

Assays

Grating-coupled interferometry (GCI)

Structure-Activity Relationships

Biological Data Not Yet Incorporated into this Wiki

Synthetic Chemistry

Synthetic Chemistry Overview

Surrounding Chemical Space

Desirable Compounds Not Yet Synthesised

Sources of Data

Sources of Data

FAQS

Frequently Asked Questions

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