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| 1 | +Name: The Cancer Dependency Map (DepMap) Cancer Cell Line Encyclopedia (CCLE) Dataset |
| 2 | +Description: This dataset consists of whole genome sequencing (WGS), whole exome sequencing (WES), and RNA sequencing files generated from ~1000 cancer cell lines described in Ghandi et al., 2019. |
| 3 | +Documentation: https://github.com/broadinstitute/depmap-omics-ccle |
| 4 | +Contact: https://forum.depmap.org |
| 5 | +ManagedBy: "[Cancer Data Science](https://cancerdatascience.org/), [Broad Institute](https://www.broadinstitute.org/)" |
| 6 | +UpdateFrequency: occasionally (as additional sequencings are generated for publicly-releasible CCLE models) |
| 7 | +Tags: |
| 8 | + - aws-pds |
| 9 | + - bam |
| 10 | + - biology |
| 11 | + - bioinformatics |
| 12 | + - cancer |
| 13 | + - genetic |
| 14 | + - genomic |
| 15 | + - Homo sapiens |
| 16 | + - life sciences |
| 17 | + - short read sequencing |
| 18 | + - transcriptomics |
| 19 | + - whole exome sequencing |
| 20 | + - whole genome sequencing |
| 21 | +License: https://grants.nih.gov/policy-and-compliance/policy-topics/sharing-policies/accessing-data/using-genomic-data |
| 22 | +Citation: Ghandi, Huang, Jané-Valbuena et al. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature 569, 503–508 (2019). https://doi.org/10.1038/s41586-019-1186-3 |
| 23 | +Resources: |
| 24 | + - Description: CRAM/BAM files (and their corresponding CRAI/BAI indexes) for RNA, WES, and WGS samples released by The Cancer Dependency Map (DepMap) as part of the Cancer Cell Line Encyclopedia (CCLE) project |
| 25 | + ARN: arn:aws:s3:::depmap-omics-ccle |
| 26 | + Region: us-east-1 |
| 27 | + Type: S3 Bucket |
| 28 | + - Description: Notifications for new depmap-omics-ccle data |
| 29 | + ARN: arn:aws:sns:us-east-1:019511184952:depmap-omics-ccle-object_created |
| 30 | + Region: us-east-1 |
| 31 | + Type: SNS Topic |
| 32 | +DataAtWork: |
| 33 | + Tutorials: |
| 34 | + - Title: DepMap Omics CCLE data on the AWS Open Data Registry |
| 35 | + URL: https://github.com/broadinstitute/depmap-omics-ccle |
| 36 | + AuthorName: Devin McCabe |
| 37 | + Tools & Applications: |
| 38 | + - Title: The Cancer Dependency Map (DepMap) |
| 39 | + URL: https://depmap.org |
| 40 | + AuthorName: Arafeh, Shibue, Dempster et al. |
| 41 | + - Title: Cancer Cell Line Encyclopedia (CCLE) |
| 42 | + URL: https://sites.broadinstitute.org/ccle |
| 43 | + AuthorName: Ghandi, Huang, Jané-Valbuena et al. |
| 44 | + Publications: |
| 45 | + - Title: Next-generation characterization of the Cancer Cell Line Encyclopedia |
| 46 | + URL: https://www.nature.com/articles/s41586-019-1186-3 |
| 47 | + AuthorName: Ghandi, Huang, Jané-Valbuena et al. |
| 48 | + - Title: The present and future of the Cancer Dependency Map |
| 49 | + URL: https://www.nature.com/articles/s41568-024-00763-x |
| 50 | + AuthorName: Arafeh, Shibue, Dempster et al. |
| 51 | + AuthorURL: https://depmap.org |
| 52 | + - Title: Partial gene suppression improves identification of cancer vulnerabilities when CRISPR-Cas9 knockout is pan-lethal |
| 53 | + URL: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-03020-w |
| 54 | + AuthorName: Krill-Burger, Dempster, Borah et al. |
| 55 | + - Title: Genetic dependencies associated with transcription factor activities in human cancer cell lines |
| 56 | + URL: https://www.sciencedirect.com/science/article/pii/S2211124724005035 |
| 57 | + AuthorName: Thatikonda, Supper, Wachter et al. |
| 58 | + - Title: Bridging the gap between cancer cell line models and tumours using gene expression data |
| 59 | + URL: https://www.nature.com/articles/s41416-021-01359-0 |
| 60 | + AuthorName: Noorbakhsh, Vazquez & McFarland |
| 61 | + - Title: Integrated cross-study datasets of genetic dependencies in cancer |
| 62 | + URL: https://www.nature.com/articles/s41467-021-21898-7 |
| 63 | + AuthorName: Pacini, Dempster, Boyle et al. |
| 64 | + - Title: Machine learning multi-omics analysis reveals cancer driver dysregulation in pan-cancer cell lines compared to primary tumors |
| 65 | + URL: https://www.nature.com/articles/s42003-022-04075-4 |
| 66 | + AuthorName: Sanders, Chandra, Zebarjadi et al. |
| 67 | + - Title: "The Network Zoo: a multilingual package for the inference and analysis of gene regulatory networks" |
| 68 | + URL: https://link.springer.com/article/10.1186/s13059-023-02877-1 |
| 69 | + AuthorName: Ben Guebila, Wang, Lopes-Ramos et al. |
| 70 | +ADXCategories: |
| 71 | + - Healthcare & Life Sciences Data |
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