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h2gene estimates for 17,437 genes and 25 traits available for download

Estimates of h2gene and MAF-partitioned h2gene for the 17,437 genes and 25 traits analyzed in Burch, Hou, et al. (2022) are available for download here.

• H2GENE_ALL_MEAN is the posterior mean of total h2gene
• H2GENE_RARE_MEAN is the posterior mean of the rare variant component of h2gene (0.5% < MAF < 1%)
• H2GENE_LF_MEAN is the posterior mean of the low-frequency variant component of h2gene (1% < MAF < 5%)
• H2GENE_COMMON_MEAN is the posterior mean of the common variant component of h2gene (MAF > 5%)
• H2GENE_*_SD are the posterior standard deviations corresponding to each estimand (ALL, RARE, LF, and COMMON)
• H2GENE_*_LOWER and H2GENE_*_UPPER are the lower and upper bounds of the 90% credible intervals for each estimand (ALL, RARE, LF, and COMMON)
• *_CAUSAL_NUM_MEAN (and *_CAUSAL_NUM_SD) are the expected numbers of causal variants contributing to each h2gene estimate (and corresponding standard deviations)
• The full names of the UKB traits in TRAIT can be found here.

Metadata for the genes (chromosome, gene start/stop positions, number of variants in estimand, etc.) are also provided here.