CoOPER-Labs

Cognitive Operational & Performance Enhancement Research Laboratory

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Research Disclaimer: Independent investigational studies. No liability assumed for experimental replication or adverse outcomes.

Privately Funded Research Objectives

Establishing deterministic methodologies for targeted adult neuroplasticity modulation through:

1. Synaptic Activation Protocols: Targeted stimulation of specific neural circuits
2. Cognitive Enhancement Paradigms: Evidence-based performance optimization strategies
3. Predictive Modeling Framework: Quantitative assessment of intervention efficacy
4. Outcome Validation Metrics: Reproducible, statistically significant functional improvements
5. Therapeutic Applications: Amelioration of attention deficit disorders and associated neurodevelopmental phenotypes

Primary Research Goal: Personal ADHD/ADD Remediation

Investigational Focus: Development and validation of personalized neuroplasticity interventions for the systematic amelioration of attention deficit hyperactivity disorder (ADHD) and attention deficit disorder (ADD) symptomatology, with particular emphasis on:

1. Attentional Network Rehabilitation: Targeted enhancement of sustained and selective attention mechanisms through evidence-based neuromodulation protocols
2. Executive Function Restoration: Systematic improvement of inhibitory control, cognitive flexibility, and working memory capacity
3. Selective Neurodivergent Phenotype Modulation: Targeted elimination of adverse cognitive and behavioral manifestations while preserving beneficial neurodivergent traits and cognitive advantages
4. Functional Outcome Maximization: Achievement of clinically meaningful improvements in academic, occupational, and social functioning domains

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Experimental Validation Criteria

Primary Endpoints: Statistically significant, reproducible cognitive enhancement demonstrating:

1. Temporal consistency across measurement intervals
2. Quantifiable effect sizes exceeding placebo thresholds
3. Double-blind validated improvements in standardized cognitive assessments

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Taxonomic Classification of Cognitive Functions

1. Attentional Networks

Research Priority	Cognitive Construct	Latin Nomenclature	Simple Definition	Prerequisite Functions	Neurochemical Pathways & Anatomical Substrates	Proposed Intervention Strategy
1	Sustained Attention	Vigilantia Continuata	Staying focused on one task for extended periods	Arousal maintenance, alertness regulation	Locus coeruleus noradrenergic projections → prefrontal cortex/parietal cortex; Basal forebrain cholinergic → cortical mantle	Transcranial direct current stimulation targeting LC/PFC + acetylcholinesterase inhibition + vigilance training protocols
6	Selective Attention	Attentio Selectiva	Focusing on relevant information while ignoring distractions	Sustained attention, response inhibition	LC noradrenergic + VTA dopaminergic → frontal eye fields/temporoparietal junction; Thalamic gating mechanisms	Theta-burst transcranial magnetic stimulation → FEF + noradrenergic modulators + attention bias modification paradigms
13	Divided Attention	Attentio Parallela	Managing multiple tasks or information sources simultaneously	Sustained attention, cognitive control flexibility	LC noradrenergic → distributed cortical networks; Striatal dopamine for task-switching	Multi-site high-definition tDCS + dual n-back training + alpha/theta neurofeedback

2. Memory Systems

Research Priority	Cognitive Construct	Latin Nomenclature	Simple Definition	Prerequisite Functions	Neurochemical Pathways & Anatomical Substrates
2	Working Memory	Memoria Operativa	Temporarily holding and manipulating information in mind	Attentional control, inhibitory regulation	VTA dopaminergic → dorsolateral prefrontal cortex; GABAergic interneuronal circuits in PFC
5	Short-term Memory	Memoria Temporaria	Briefly storing information for immediate use	Attentional focus, working memory buffer	Basal forebrain cholinergic → hippocampal formation; Glutamatergic CA3-CA1 circuitry
8	Long-term Consolidation	Consolidatio Memoriae	Converting short-term memories into permanent storage	Attentional encoding, working memory maintenance	Basal forebrain cholinergic → hippocampus; Metabotropic glutamate receptor-CREB signaling cascade
9	Memory Retrieval	Evocatio Memoriae	Accessing and recalling stored information	Attentional search, working memory manipulation	Hippocampal CA1 glutamatergic output; Cholinergic modulation from medial septum/diagonal band
15	Episodic Memory	Memoria Episodica	Remembering specific personal experiences and events	Long-term systems, attentional binding, working memory	Cholinergic input → medial temporal lobe; Glutamatergic long-term potentiation in CA1; VTA dopaminergic
16	Semantic Memory	Memoria Semantica	Storing general knowledge and facts about the world	Long-term storage, verbal comprehension networks	Temporal cortex glutamatergic circuits; Acetylcholine neuromodulation

3. Executive Control Networks

Research Priority	Cognitive Construct	Latin Nomenclature	Simple Definition	Prerequisite Functions	Neurochemical Pathways & Anatomical Substrates
3	Inhibitory Control	Inhibitio Executiva	Stopping inappropriate responses and controlling impulses	Attentional regulation, working memory maintenance	Raphe serotonergic → prefrontal cortex; GABAergic interneurons in anterior cingulate/inferior frontal gyrus
7	Cognitive Flexibility	Flexibilitas Executiva	Switching between different tasks or mental strategies	Working memory, inhibitory control	VTA dopaminergic → anterior cingulate cortex/orbitofrontal cortex; LC noradrenergic → PFC
12	Strategic Planning	Planificatio Strategica	Organizing steps to achieve future goals	Working memory, cognitive flexibility	VTA dopaminergic → dorsolateral/ventromedial PFC; LC noradrenergic → frontal networks
14	Problem-solving	Resolutio Problematum	Finding solutions to complex or novel challenges	Working memory, cognitive flexibility, sustained attention	VTA dopaminergic → prefrontal cortex; NMDA receptor-mediated cortical processing
32	Metacognitive Control	Metacognitio Executiva	Thinking about thinking and monitoring your own thoughts	Working memory, attentional monitoring, abstract reasoning	Medial prefrontal dopaminergic circuits; Cholinergic uncertainty signaling

4. Processing Efficiency

Research Priority	Cognitive Construct	Latin Nomenclature	Simple Definition	Prerequisite Functions	Neurochemical Pathways & Anatomical Substrates
4	Processing Velocity	Velocitas Cognitiva	How quickly you can think and perform mental tasks	Attentional focus, motor coordination	Substantia nigra dopaminergic → striatum; Oligodendrocyte myelination efficiency

5. Linguistic Networks

Research Priority	Cognitive Construct	Latin Nomenclature	Simple Definition	Prerequisite Functions	Neurochemical Pathways & Anatomical Substrates
10	Verbal Comprehension	Comprehensio Linguistica	Understanding spoken and written language	Attention, working memory, long-term memory	Basal forebrain cholinergic → Wernicke's area; VTA dopaminergic → left hemisphere
17	Expressive Language	Productio Linguistica	Speaking and expressing thoughts verbally	Verbal comprehension, working memory, motor control	Broca's area dopaminergic/cholinergic; Motor cortex GABAergic regulation
18	Reading Comprehension	Decodificatio Textus	Understanding written text and extracting meaning	Verbal comprehension, attention, working memory	Left hemisphere cholinergic; Dorsal/ventral stream dopaminergic modulation
19	Written Expression	Compositio Scripta	Communicating thoughts through writing	Expressive language, working memory, motor coordination	Motor cortex dopaminergic/GABAergic; Cerebellar-cortical cholinergic circuits
20	Phonological Processing	Processus Phonologicus	Processing and manipulating speech sounds	Attention, working memory, auditory processing	Superior temporal cholinergic; Auditory cortex GABAergic inhibition

6. Visuospatial Networks

Research Priority	Cognitive Construct	Latin Nomenclature	Simple Definition	Prerequisite Functions	Neurochemical Pathways & Anatomical Substrates
11	Visuospatial Processing	Processus Visuospatialis	Understanding spatial relationships and visual information	Attention, working memory	VTA dopaminergic → parietal cortex; Cholinergic input → visual areas V1-V5
21	Spatial Reasoning	Ratiocinatio Spatialis	Mentally manipulating objects and understanding 3D relationships	Visuospatial processing, working memory	Right parietal dopaminergic; Glutamatergic cortico-cortical circuits
22	Mental Rotation	Rotatio Cognitiva	Imagining how objects look when rotated in space	Visuospatial processing, working memory	Parietal cortex dopaminergic; Motor cortex cholinergic for motor simulation
23	Visual Perception	Perceptio Visualis	Processing and interpreting what you see	Attention, processing speed	Visual cortex V1-V4 glutamatergic; GABAergic lateral inhibition
24	Pattern Recognition	Recognitio Configuralis	Identifying familiar shapes, objects, or arrangements	Visual perception, working memory	Inferotemporal dopaminergic; Glutamatergic feature integration
25	Constructional Abilities	Constructio Visuomotoria	Building, drawing, or assembling things accurately	Visuospatial processing, motor control, planning	Parietal-motor dopaminergic/cholinergic; Cerebellar GABAergic modulation

7. Higher-Order Reasoning Networks

Research Priority	Cognitive Construct	Latin Nomenclature	Simple Definition	Prerequisite Functions	Neurochemical Pathways & Anatomical Substrates
26	Logical Reasoning	Ratiocinatio Formalis	Using rules and logic to solve problems systematically	Working memory, cognitive flexibility, sustained attention	Dorsolateral PFC dopaminergic; Glutamatergic association networks
27	Abstract Reasoning	Ratiocinatio Abstracta	Understanding concepts and ideas beyond concrete examples	Working memory, cognitive flexibility, semantic memory	Rostral PFC dopaminergic; Glutamatergic higher-order integration
30	Analogical Reasoning	Ratiocinatio Analogica	Finding similarities and connections between different situations	Abstract reasoning, working memory, semantic memory	Rostral PFC dopaminergic; Glutamatergic relational processing
31	Critical Analysis	Analytica Critica	Evaluating information objectively and identifying flaws in reasoning	Logical reasoning, working memory, inhibitory control	Dorsolateral PFC/ACC dopaminergic; Glutamatergic evaluative networks

8. Learning & Adaptation Networks

Research Priority	Cognitive Construct	Latin Nomenclature	Simple Definition	Prerequisite Functions	Neurochemical Pathways & Anatomical Substrates
28	Acquisition Mechanisms	Mechanismus Acquisitionis	Learning new information and skills effectively	Attention, working memory, long-term memory	VTA dopaminergic → striatum; Hippocampal cholinergic-glutamatergic interactions
29	Procedural Learning	Discendum Procedurale	Learning automatic skills and habits through practice	Motor control, working memory, procedural memory	Striatal dopaminergic; Cerebellar GABA-glutamate circuits; Motor cortex
33	Cognitive Transfer	Transferentia Cognitiva	Applying learned skills to new and different situations	Learning mechanisms, abstract reasoning, cognitive flexibility	Hippocampal-cortical dopaminergic/glutamatergic; Pattern completion networks
34	Neural Plasticity	Plasticitas Neuralis	The brain's ability to reorganize and form new connections	All cognitive domains, learning substrates	BDNF-TrkB signaling pathways; NMDA-dependent long-term potentiation; Dopamine-modulated synaptic plasticity

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Neurochemical Nomenclature

Primary Neurotransmitter Systems:

• NE: Norepinephrine (Noradrenaline)
• DA: Dopamine
• ACh: Acetylcholine
• 5-HT: Serotonin (5-Hydroxytryptamine)
• Glu: Glutamate
• GABA: Gamma-aminobutyric acid

Neuroanatomical Regions:

• PFC: Prefrontal Cortex
• dlPFC: Dorsolateral Prefrontal Cortex
• vmPFC: Ventromedial Prefrontal Cortex
• ACC: Anterior Cingulate Cortex
• IFG: Inferior Frontal Gyrus
• OFC: Orbitofrontal Cortex
• FEF: Frontal Eye Fields
• TPJ: Temporoparietal Junction
• MTL: Medial Temporal Lobe
• MS/DB: Medial Septum/Diagonal Band Complex

Subcortical Nuclei:

• LC: Locus Coeruleus
• VTA: Ventral Tegmental Area

Molecular Targets:

• CREB: cAMP Response Element-Binding Protein
• BDNF: Brain-Derived Neurotrophic Factor
• TrkB: Tropomyosin Receptor Kinase B
• LTP: Long-Term Potentiation
• NMDA: N-methyl-D-aspartate Receptor
• mGluR: Metabotropic Glutamate Receptor

Functional Domain Characteristics

Attentional Networks: Foundational gating mechanisms regulating information flow across distributed cognitive architectures.

Memory Systems: Temporally-stratified encoding, consolidation, and retrieval mechanisms spanning multiple timescales and content domains.

Executive Control Networks: Superordinate regulatory processes governing cognitive resource allocation and behavioral adaptation.

Processing Efficiency: Temporal dynamics of neural computation and information transmission velocity.

Linguistic Networks: Specialized left-lateralized circuits for language comprehension, production, and symbolic processing.

Visuospatial Networks: Dorsal and ventral stream processing for spatial cognition and visuomotor integration.

Higher-Order Reasoning Networks: Rostral prefrontal circuits mediating abstract thought, logical inference, and complex problem-solving.

Learning & Adaptation Networks: Experience-dependent synaptic modification mechanisms enabling behavioral optimization and skill acquisition.