TBXT-CDX2-Analysis

This repository contains R scripts used for snRNA-seq and snATAC-seq analyses.

Corresponding data files can be found on GEO:

CDX2-Het, CDX2-KO = GSE251813

WT, TBXT-Het, TBXT-KO = GSE245998

Corresponding publications include:

Bulger, E. A., et. al. (2024). CDX2 dose-dependently influences the gene regulatory network underlying human extraembryonic mesoderm development. BioRxiv. Under Review.

Bulger, E. A., et. al. (2024). TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids. Development. Accepted Manuscript.