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12 changes: 11 additions & 1 deletion README.md
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<a href="http://bioconda.github.io/recipes/guide-counter/README.html"><img src="https://img.shields.io/conda/dn/bioconda/guide-counter.svg?label=bioconda" alt="Bioconda"></a>
<a href="https://doi.org/10.5281/zenodo.6375791"><img src="https://zenodo.org/badge/DOI/10.5281/zenodo.6375791.svg" alt="DOI"></a>
<br>
A better, faster way to count guides in CRISPR screens.
</p>

A better, faster way to count guides in CRISPR screens.

<p>
<a href float="left"="https://fulcrumgenomics.com"><img src=".github/logos/fulcrumgenomics.svg" alt="Fulcrum Genomics" height="100"/></a>
</p>

[Visit us at Fulcrum Genomics](www.fulcrumgenomics.com) to learn more about how we can power your Bioinformatics with guide-counter and beyond.

<a href="mailto:contact@fulcrumgenomics.com?subject=[GitHub inquiry]"><img src="https://img.shields.io/badge/Email_us-brightgreen.svg?&style=for-the-badge&logo=gmail&logoColor=white"/></a>
<a href="https://www.fulcrumgenomics.com"><img src="https://img.shields.io/badge/Visit_Us-blue.svg?&style=for-the-badge&logo=wordpress&logoColor=white"/></a>

## Overview

`guide-counter` is a tool for processing FASTQ files from CRISPR screen experiments to generate a matrix of per-sample guide counts. It can be used as a faster, more accurate, drop in replacement for `mageck count`. By default `guide-counter` will look for guide seqeunces in the reads with 0 or 1 mismatches vs. the expected guides, but can be run in exact matching mode.
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