Episode 47

Author: kescobo

episodes/episode047.md

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+using Dates
+title = "If you're a hammer"
+season = 2
+episode = 47
+date = DateTime(2025, 10, 23, 13, 0, 0)
+tags = [
+    "inflammation", 
+    "innate immunity",
+    "autoimmunity",
+    "TLR7", 
+    "RNA",
+    "SLE",
+    "cell biology"
+]
+rss_descr = """
+In this episode, Matt and Kevin talk about glycoRNAs and inflammation,
+but Matt insists that it's really about Lupus
+"""
+rss_title = title
+rss_pubdate = date
+rss_enclosure = "https://archive.org/download/audiommunity_episode047/audiommunity_episode047.mp3"
+episode_length = "74245371"
+itunes_duration = "3598"
+youtube = "https://youtu.be/26AQC5wEh4A"
++++
+
+Against all expectations, there's RNA attached to the surface of cells.
+Why? Who knows! 
+But it almost certainly has implications for the immune system.
+As Matt and Kevin discuss in this episode,
+it turns out that cells add sugars to these RNAs (glycosylation)
+to hide them from the innate immune system,
+especially during apoptosis.
+
+## Links
+
+- The Paper: [RNA N-glycosylation enables immune evasion and homeostatic efferocytosis](https://doi.org/10.1038/s41586-025-09310-6)
+- [Previous Audiommunity episode about Lupus](/episodes/episode028)
+- [Previous Audiommunity epiode about innate immunity](/episodes/episode003)
+- [Previous Audiommunity episode about cGAS](/episodes/episode037)
+
+