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…nk tolerance drug_synergy_tool.py — Bug #7 (CRITICAL): ZIP fallback was Bliss, not ZIP - ZIP requires Hill curve fitting; without it a Bliss independence surface was silently returned labelled as a ZIP delta score — scientifically wrong - Now returns a clear error naming the drug(s) that failed Hill fitting and directing the user to calculate_bliss for a non-parametric alternative drug_synergy_tool.py — Bug #8: Emax upper bound 1.5 in Loewe/CI Hill fitter - _fit_hill_for_loewe uses fractional inhibition (0-1); Emax > 1 is physically impossible, yet the scipy curve_fit upper bound allowed 1.5 - Corrected to 1.0 (Loewe & Muischnek 1926; Chou & Talalay 1984) nca_tool.py — Bug #4: terminal slope accepted 2 instead of 3 post-Tmax points - FDA NCA guidance requires 3+ points for lambda_z: a 2-point linear regression is a perfect fit by construction (R2=1 trivially), giving no quality signal - Now requires 3+ post-Tmax positive concentrations before using the full set; falls back to last n_points otherwise survival_tool.py — Bug #6: log-rank zero-variance check used absolute tolerance - Threshold 1e-10 too tight for large studies: float rounding errors over many event times scale as N x 2.2e-16, so 1e-10 would erroneously reject valid proportional distributions in datasets with thousands of events - Replaced with relative tolerance: 1e-8 x total_events (safe up to 10^7 events)
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Hi there,
This pull request shares a security update on ToolUniverse.
We also have an entry for ToolUniverse in our directory, MseeP.ai, where we provide regular security and trust updates on your app.
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CEO/SkyDeck AI
Founder of MseeP.ai
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Here are our latest evaluation results of ToolUniverse
Security Scan Results
Security Score: 100/100
Risk Level: low
Scan Date: 2025-06-13
Score starts at 100, deducts points for security issues, and adds points for security best practices
This security assessment was conducted by MseeP.ai, an independent security validation service for MCP servers. Visit our website to learn more about our security reviews.