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Morgagni-Stewart-Morel Syndrome: Add evidence for diabetes insipidus phenotype #312

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Description

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Problem

In PR #284 (Morgagni-Stewart-Morel Syndrome), the automated review noted that the diabetes insipidus phenotype lacks supporting evidence.

Source: Claude review comment in PR #284

"The diabetes insipidus phenotype has no evidence items. The description states it 'has been reported' but doesn't provide a reference."

Location: kb/disorders/Morgagni-Stewart-Morel_Syndrome.yaml, lines 554-564

Current State

The diabetes insipidus phenotype is included in the entry with frequency annotation HP_0040284 (very rare), but has no evidence items to support its inclusion.

The description states: "Diabetes insipidus has been reported rarely in association with MSM syndrome, potentially related to hypothalamic-pituitary dysfunction."

Proposed Solutions

Option 1: Add supporting evidence if available

  • Search the literature for case reports or studies documenting diabetes insipidus in MSM syndrome patients
  • Add evidence items with PMIDs, snippets, and explanations

Option 2: Add a clarifying note
If direct evidence is unavailable but historically reported:

description: >
  Diabetes insipidus has been reported rarely in historical case series
  of MSM syndrome, potentially related to hypothalamic-pituitary dysfunction.
  However, this association is poorly documented in modern literature.

Option 3: Remove the phenotype
If insufficient evidence exists and it's not well-documented, consider removing it entirely.

Guidelines Reference

Per dismech guidelines (CLAUDE.md):

"Per dismech guidelines, phenotypes without evidence are acceptable but less ideal from a compliance perspective."

While acceptable, adding evidence would improve the entry's compliance score and scientific rigor.

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