Protein Structure Analysis of SARS-CoV-2 Spike Protein

Project overview

This beginner structural bioinformatics project analyzes the SARS-CoV-2 spike glycoprotein using structure 6VSB.

Dataset

• RCSB Protein Data Bank
• PDB ID: 6VSB

Tools

• Git
• Python
• Conda
• PyMOL

Results

• figures/6VSB_trimer.png
• figures/6VSB_domains_chainA.png
• figures/6VSB_RBD.png
• figures/6VSB_D614_hotspot.png
• results/domain_table.tsv
• results/mutation_hotspot_report.md

Reproducible Commands

wget -O data/raw/6VSB.pdb https://files.rcsb.org/download/6VSB.pdb pymol -cq scripts/first_view.pml pymol -cq scripts/domain_view.pml pymol -cq scripts/rbd_view.pml pymol -cq scripts/d614_hotspot.pml