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Unclear state of duplex demultiplexing

documentationImprovements or additions to documentationImprovements or additions to documentation

Status: Open.

#1569 In nanoporetech/dorado;

· hjarnek opened on Feb 5, 2026

Can RNA models distinguish U from T?

documentationImprovements or additions to documentationImprovements or additions to documentation

Status: Open.

#1568 In nanoporetech/dorado;

· Appenzee opened on Feb 5, 2026

dorado correct 1.3.1 produces drastically fewer reads than version 1.0.2

read_correctionRead error correctionRead error correction

Status: Open.

#1566 In nanoporetech/dorado;

· baptisteImbert opened on Feb 2, 2026

sup@5.2.0 basecalled reads lower quality than sup@5.0.0

Status: Open.

#1565 In nanoporetech/dorado;

· samuelmontgomery opened on Jan 27, 2026

Barcode trimming is overly aggressive

Status: Open.

#1564 In nanoporetech/dorado;

· jts opened on Jan 24, 2026

Output folder of demux incomprehensible

Status: Open.

#1563 In nanoporetech/dorado;

· stefandiederich opened on Jan 23, 2026

Inconsistent Poly(A) Tail Detection between Dorado versions

polyAIssue related to polyA tail estimationIssue related to polyA tail estimation

Status: Open.

#1562 In nanoporetech/dorado;

· nemitheasura opened on Jan 23, 2026

Systematic evaluation of computational tools for RNA modification detection

Status: Open.

#1560 In nanoporetech/dorado;

· SuhasSrinivasan opened on Jan 22, 2026

dorado polish - RAM of 768 GB not sufficient

polishIssues related to polishingIssues related to polishing

Status: Open.

#1559 In nanoporetech/dorado;

· colindaven opened on Jan 22, 2026

rna004_130bps_hac@v5.2.0(m5C) vs rna004_130bps_sup@v5.2.0 m5C_2OmeC

modsFor issues related to modified base callingFor issues related to modified base calling

Status: Open.

#1558 In nanoporetech/dorado;

· kamaloxfordpathology opened on Jan 20, 2026

Interpreting output of dorado demux using custom barcodes at both ends

barcodeIssues related to barcodingIssues related to barcoding

documentationImprovements or additions to documentationImprovements or additions to documentation

Status: Open.

#1556 In nanoporetech/dorado;

· Kyung-TaeLee opened on Jan 19, 2026

Dorado duplex tries downloading model, altough indicated as present

duplexIssues related to duplex basecallingIssues related to duplex basecalling

Status: Open.

#1553 In nanoporetech/dorado;

· Thomieh73 opened on Jan 13, 2026