F: Protein Scores and Group Classification

Table of Offset Based Protein Scores and Group Classification

This a list of scores to apply at various offsets to calculate an allele’s functional distance from DPB1*09:01 and how that score is used to determine TCE group.

Offset Scores

· offset 8:
      o   L: 0.06
· offset 9:
      o   F: 0.69
      o   Y: 0.87
· offset 11:
      o   G: 0.96
· offset 35:
      o   L: 0.05
      o   Y: 0.85
· offset 55:
      o   A: 0.73
· offset 56:
      o   A: 0.04
· offset 57:
      o   E: 0.12
· offset 69:
      o   K: 0.95
· offset 76:
      o   M: 0.54
· offset 84:
      o   G: 0.93

Group Classification:

(Group 0):
      o   null allele
 Group 1:
      o   Score <= 0.6
 Group 2:
      o   0.6 < Score <= 2.0
 Group 3:
      o   2.0 < Score