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Add stratum corneum of esophageal epithelium term #3540

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Add stratum corneum of esophageal epithelium term #3540

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Add stratum corneum of esophageal epithelium term
May 20, 2025
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Merge branch 'master' into issue-3423
matentzn Jan 19, 2026
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9 changes: 9 additions & 0 deletions src/ontology/uberon-edit.obo
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Expand Up @@ -225722,6 +225722,15 @@ is_a: UBERON:0006914 ! squamous epithelium
relationship: has_part CL:4030023 ! respiratory tract hillock cell
relationship: part_of UBERON:0007196 ! tracheobronchial tree

[Term]
id: UBERON:8910025
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Copilot AI Jan 19, 2026

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This term creates a duplicate entry for "stratum corneum of esophageal epithelium". The same term already exists as UBERON:8700003 on lines 225522-225528. Instead of creating a new term with ID UBERON:8910025, you should either update the existing term UBERON:8700003 or remove it if this is meant to replace it.

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name: stratum corneum of esophageal epithelium
def: "The outermost layer of the stratified squamous epithelium lining the esophagus, composed of several layers of flattened, anucleated keratinocytes called corneocytes. It forms the primary protective barrier against mechanical, chemical, and microbial insults, while regulating permeability and contributing to tissue integrity. This layer is characterized by corneocytes embedded in a lipid-rich extracellular matrix, providing mechanical reinforcement and maintaining essential barrier functions of the esophageal lining." [PMID:21126700, PMID:26019440, doi:10.1038/gimo15]
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The definition describes the stratum corneum as containing "anucleated keratinocytes called corneocytes" and "lipid-rich extracellular matrix", which are characteristics of keratinized epithelium. However, this term is classified as "non-keratinized stratified squamous epithelium" (UBERON:0010304). The esophageal epithelium is indeed non-keratinized under normal conditions, so the definition should be revised to remove references to fully keratinized features like anucleated cells and describe it as containing flattened cells that may retain nuclei, consistent with non-keratinized tissue.

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is_a: UBERON:0010304 ! non-keratinized stratified squamous epithelium
relationship: dc-contributor https://orcid.org/0009-0005-7919-4905
relationship: part_of UBERON:0001976 ! epithelium of esophagus
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This term uses "part_of UBERON:0001976 ! epithelium of esophagus", but the existing related terms (UBERON:8700002 stratum spinosum and UBERON:8700003 stratum corneum on lines 225518 and 225527) use "part_of UBERON:0001043 ! esophagus". For consistency with the existing esophageal epithelium layer terms, this should use "part_of UBERON:0001043 ! esophagus" instead.

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relationship: superficial_to UBERON:8700002 ! stratum spinosum of esophageal epithelium

[Typedef]
id: aboral_to
name: aboral to
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