Updated drugs concepts

[VeronicaMuthee]

Overview:

• v3: 87 drug concepts
• v4: 146 drug concepts
• Net addition: 59 new drug concepts
• Removed: 0 concepts
• Unchanged: 87 concepts (all v3 concepts retained)

Categories of new drugs added

HIV/AIDS Treatment (23 concepts)

• Single agents: Abacavir, Emtricitabine, Efavirenz, Dolutegravir, Raltegravir, Atazanavir, Darunavir, Etravirine, Tenofovir alafenamide
• Combination therapies: Abacavir/dolutegravir/lamivudine, Efavirenz/emtricitabine/tenofovir, Efavirenz/lamivudine/tenofovir, Emtricitabine/rilpivirine/tenofovir combinations, Lamivudine combinations with
  nevirapine/zidovudine and raltegravir, plus others
• Protease inhibitor combinations: Atazanavir and ritonavir

Tuberculosis Treatment (8 concepts)

• Single agents: Bedaquiline, Clofazimine, Cycloserine, Pretomanid, Delamanid
• Combination therapies: Ethambutol/isoniazid, Rifampicin combinations (with isoniazid, with isoniazid/ethambutol, with isoniazid/pyrazinamide/ethambutol), Isoniazid/Rifapentine

Antibiotics/Anti-infectives (6 concepts)

• Ciprofloxacin, Erythromycin, Sulfamethoxazole/trimethoprim, Sulfadiazine, Dapsone, Acyclovir

Antifungals (3 concepts)

• Amphotericin B, Amphotericin B lipid complex, Amphotericin B liposomal

Cardiovascular/Emergency Drugs (3 concepts)

• Amiodarone, Alteplase, Tranexamic acid

Other Therapeutic Categories:

• Immunosuppressant: Adalimumab
• Diuretics: Acetazolamide, Amiloride
• Anxiolytic: Alprazolam
• Contrast agents: Diatrizoate, Iopanoic acid
• Antidotes/Chelators: Prussian blue, Equine diphtheria antitoxin
• Dermatologic: Benzyl benzoate, Salicylic acid
• Nutritional: Folic acid, Albumin (human)
• GI/Other: Sodium alginate, Cilastatin/imipenem

Key Improvements:

1. Expanded HIV treatment options with modern combination therapies and newer agents
2. Enhanced TB treatment capabilities including drug-resistant TB options
3. Broader antibiotic coverage for various infections
4. Specialized treatments for emergency/critical care scenarios
5. Better support for complex medical conditions requiring specialized drugs

The update significantly enhances the drug formulary from a basic 87-drug starter pack to a comprehensive 146-drug collection suitable for more complex clinical scenarios.