NYU Langone's Health Tech Datathon, May 10 and 11, 2019

Is capillary leak index (CLI) a marker of severity of illness in sepsis?

Study to test if capillary leak index (CLI) is a marker of severity of illness in sepsis.

• Sepsis is an important cause of morbidity and mortality
• Capillary leak, the escape of protein-rich fluid leaks out of vessels into organs, is an important part of sepsis
• CLI can be estimated by the change in hematocrit after IV fluids
• Changes in hematocrit would be inversely proportional to the degree of capillary leak

Null hypothesis

Septic patients with a high CLI will have the same risk for morbidity and mortality as patients with a low CLI

Cohort

Patients w/ sepsis (eICU database)

Exposure

CLI (quartiles of severity)

Outcome

In-hospital mortality