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1 | | -{ |
2 | | - "title": "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record", |
3 | | - "upload_type": "publication", |
4 | | - "publication_type": "technicalnote", |
5 | | - "description": "<p>This repository provides the open scientific disclosure and LaTeX documentation for the <b>Tri-Modal Antifungal Catheter Lock (TCL)</b> — a novel, non-systemic antifungal catheter lock composition designed to eradicate <i>Candidozyma (Candida) auris</i> and other resistant fungal biofilms. The TCL integrates three synergistic mechanisms: (1) echinocandin antifungal activity, (2) β-1,3-glucanase enzymatic digestion of the extracellular matrix, and (3) gallium(III)/EDTA-mediated iron substitution disrupting metabolic integrity. Together, these effects yield ≥3-log biofilm reduction within 90 minutes without catheter degradation.</p>", |
6 | | - "creators": [ |
7 | | - { |
8 | | - "name": "Valamontes, Antonios", |
9 | | - "affiliation": "Kapodistrian Academy of Science", |
10 | | - "orcid": "0009-0008-5616-7746" |
11 | | - }, |
12 | | - { |
13 | | - "name": "Adamopoulos, Ioannis", |
14 | | - "affiliation": "Public Health and Environmental Inspector, Department of Environmental Hygiene and Public Health Inspections, Region of Attica, Hellenic Republic" |
15 | | - } |
16 | | - ], |
17 | | - "contributors": [ |
18 | | - { |
19 | | - "name": "Kapodistrian Academy of Science", |
20 | | - "type": "HostingInstitution" |
21 | | - } |
22 | | - ], |
23 | | - "keywords": [ |
24 | | - "Candida auris", |
25 | | - "biofilm", |
26 | | - "catheter lock", |
27 | | - "echinocandin", |
28 | | - "β-1,3-glucanase", |
29 | | - "gallium", |
30 | | - "EDTA", |
31 | | - "infection control", |
32 | | - "public health" |
33 | | - ], |
34 | | - "language": "eng", |
35 | | - "license": "cc-by-nc-4.0", |
36 | | - "access_right": "open", |
37 | | - "related_identifiers": [ |
38 | | - { |
39 | | - "relation": "isSupplementTo", |
40 | | - "identifier": "https://github.com/Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL" |
41 | | - } |
42 | | - ], |
43 | | - "notes": "This proof-of-invention disclosure establishes timestamped prior-art protection. Commercial manufacturing or distribution of TCL formulations requires explicit written licensing from the inventor. Contact [email protected] for licensing inquiries.", |
44 | | - "grants": [], |
45 | | - "communities": [ |
46 | | - { |
47 | | - "identifier": "open-science" |
48 | | - } |
49 | | - ], |
50 | | - "upload_type_terms": "software, dataset, publication", |
51 | | - "version": "1.0.0", |
52 | | - "doi": "", |
53 | | - "publication_date": "2025-11-12" |
54 | | -} |
| 1 | +# CITATION.cff for Tri-Modal Antifungal Catheter Lock (TCL) |
| 2 | +# Compatible with GitHub & Zenodo DOI export |
| 3 | +cff-version: 1.2.0 |
| 4 | +message: "If you use this work, please cite it as below." |
| 5 | +title: "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record" |
| 6 | +version: "1.0.0" |
| 7 | +doi: "10.5281/zenodo.XXXXXXX" # Replace with actual DOI after Zenodo minting |
| 8 | +date-released: "2025-11-12" |
| 9 | +authors: |
| 10 | + - family-names: "Valamontes" |
| 11 | + given-names: "Antonios" |
| 12 | + affiliation: "Kapodistrian Academy of Science" |
| 13 | + |
| 14 | + orcid: "https://orcid.org/0009-0008-5616-7746" |
| 15 | + - family-names: "Adamopoulos" |
| 16 | + given-names: "Ioannis" |
| 17 | + affiliation: "Public Health and Environmental Inspector, Department of Environmental Hygiene and Public Health Inspections, Region of Attica, Hellenic Republic" |
| 18 | + |
| 19 | +abstract: > |
| 20 | + This record discloses the Tri-Modal Antifungal Catheter Lock (TCL), |
| 21 | + a non-systemic antifungal formulation combining three synergistic mechanisms: |
| 22 | + (1) echinocandin antifungal inhibition of β-glucan synthase, |
| 23 | + (2) β-1,3-glucanase enzymatic digestion of extracellular matrix polysaccharides, |
| 24 | + and (3) gallium(III)/EDTA complex-induced iron substitution disrupting |
| 25 | + metabolic integrity of fungal biofilms. Together, these interactions produce |
| 26 | + ≥3-log biofilm reduction within 90 minutes without catheter degradation. |
| 27 | + The proof of invention establishes timestamped prior-art protection |
| 28 | + for open scientific disclosure and non-commercial research collaboration. |
| 29 | + |
| 30 | +keywords: |
| 31 | + - Candida auris |
| 32 | + - biofilm |
| 33 | + - catheter lock |
| 34 | + - echinocandin |
| 35 | + - β-1,3-glucanase |
| 36 | + - gallium |
| 37 | + - EDTA |
| 38 | + - infection control |
| 39 | + - public health |
| 40 | + |
| 41 | +repository-code: "https://github.com/Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL" |
| 42 | +license: "CC-BY-NC-4.0" |
| 43 | +license-url: "https://creativecommons.org/licenses/by-nc/4.0/" |
| 44 | +type: "software" |
| 45 | +preferred-citation: |
| 46 | + type: article |
| 47 | + authors: |
| 48 | + - family-names: "Valamontes" |
| 49 | + given-names: "Antonios" |
| 50 | + - family-names: "Adamopoulos" |
| 51 | + given-names: "Ioannis" |
| 52 | + title: "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record" |
| 53 | + journal: "Kapodistrian Academy of Science" |
| 54 | + year: 2025 |
| 55 | + doi: "10.5281/zenodo.XXXXXXX" |
| 56 | + url: "https://doi.org/10.5281/zenodo.XXXXXXX" |
| 57 | + |
55 | 58 |
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