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.zenodo.json

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{
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"title": "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record",
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"upload_type": "publication",
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"publication_type": "technicalnote",
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"description": "<p>This repository provides the open scientific disclosure and LaTeX documentation for the <b>Tri-Modal Antifungal Catheter Lock (TCL)</b> — a novel, non-systemic antifungal catheter lock composition designed to eradicate <i>Candidozyma (Candida) auris</i> and other resistant fungal biofilms. The TCL integrates three synergistic mechanisms: (1) echinocandin antifungal activity, (2) β-1,3-glucanase enzymatic digestion of the extracellular matrix, and (3) gallium(III)/EDTA-mediated iron substitution disrupting metabolic integrity. Together, these effects yield ≥3-log biofilm reduction within 90 minutes without catheter degradation.</p>",
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"creators": [
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{
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"name": "Valamontes, Antonios",
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"affiliation": "Kapodistrian Academy of Science",
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"orcid": "0009-0008-5616-7746"
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},
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{
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"name": "Adamopoulos, Ioannis",
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"affiliation": "Public Health and Environmental Inspector, Department of Environmental Hygiene and Public Health Inspections, Region of Attica, Hellenic Republic"
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}
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],
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"contributors": [
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{
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"name": "Kapodistrian Academy of Science",
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"type": "HostingInstitution"
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}
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],
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"keywords": [
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"Candida auris",
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"biofilm",
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"catheter lock",
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"echinocandin",
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"β-1,3-glucanase",
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"gallium",
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"EDTA",
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"infection control",
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"public health"
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],
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"language": "eng",
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"license": "cc-by-nc-4.0",
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"access_right": "open",
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"related_identifiers": [
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{
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"relation": "isSupplementTo",
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"identifier": "https://github.com/Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL"
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}
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],
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"notes": "This proof-of-invention disclosure establishes timestamped prior-art protection. Commercial manufacturing or distribution of TCL formulations requires explicit written licensing from the inventor. Contact [email protected] for licensing inquiries.",
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"grants": [],
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"communities": [
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{
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"identifier": "open-science"
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}
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],
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"upload_type_terms": "software, dataset, publication",
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"version": "1.0.0",
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"doi": "",
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"publication_date": "2025-11-12"
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}
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# CITATION.cff for Tri-Modal Antifungal Catheter Lock (TCL)
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# Compatible with GitHub & Zenodo DOI export
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cff-version: 1.2.0
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message: "If you use this work, please cite it as below."
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title: "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record"
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version: "1.0.0"
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doi: "10.5281/zenodo.XXXXXXX" # Replace with actual DOI after Zenodo minting
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date-released: "2025-11-12"
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authors:
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- family-names: "Valamontes"
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given-names: "Antonios"
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affiliation: "Kapodistrian Academy of Science"
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orcid: "https://orcid.org/0009-0008-5616-7746"
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- family-names: "Adamopoulos"
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given-names: "Ioannis"
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affiliation: "Public Health and Environmental Inspector, Department of Environmental Hygiene and Public Health Inspections, Region of Attica, Hellenic Republic"
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abstract: >
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This record discloses the Tri-Modal Antifungal Catheter Lock (TCL),
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a non-systemic antifungal formulation combining three synergistic mechanisms:
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(1) echinocandin antifungal inhibition of β-glucan synthase,
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(2) β-1,3-glucanase enzymatic digestion of extracellular matrix polysaccharides,
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and (3) gallium(III)/EDTA complex-induced iron substitution disrupting
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metabolic integrity of fungal biofilms. Together, these interactions produce
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≥3-log biofilm reduction within 90 minutes without catheter degradation.
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The proof of invention establishes timestamped prior-art protection
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for open scientific disclosure and non-commercial research collaboration.
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keywords:
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- Candida auris
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- biofilm
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- catheter lock
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- echinocandin
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- β-1,3-glucanase
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- gallium
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- EDTA
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- infection control
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- public health
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repository-code: "https://github.com/Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL"
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license: "CC-BY-NC-4.0"
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license-url: "https://creativecommons.org/licenses/by-nc/4.0/"
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type: "software"
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preferred-citation:
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type: article
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authors:
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- family-names: "Valamontes"
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given-names: "Antonios"
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- family-names: "Adamopoulos"
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given-names: "Ioannis"
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title: "Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record"
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journal: "Kapodistrian Academy of Science"
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year: 2025
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doi: "10.5281/zenodo.XXXXXXX"
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url: "https://doi.org/10.5281/zenodo.XXXXXXX"
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