A cell-hierarchy based method for genetic association studies.
You can install the development version of Higana using devtools:
if (!requireNamespace("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("GenomicRanges")
devtools::install_github("SimonLarsen/higana")If you use Higana in your research please cite the following publication:
Hierarchical association of COPD to principal genetic components of biological systems.
Carlin DE, Larsen SJ, Sirupurapu V, Cho MH, Silverman EK, et al. (2023) Hierarchical association of COPD to principal genetic components of biological systems. PLOS ONE 18(5): e0286064. https://doi.org/10.1371/journal.pone.0286064.
If you want to contact us regarding Higana please contact us in the following order:
- Simon Larsen: simonhffh (AT) gmail (DOT) com
- Trey Ideker: tideker (AT) ucsd (DOT) edu
- Jan Baumbach: jan (DOT) baumbach (AT) wzw (DOT) tum (DOT) de