Repository for the project Chandra, J., Armengol de la Hoz, M.A., Lee, G. et al. A novel Vascular Leak Index identifies sepsis patients with a higher risk for in-hospital death and fluid accumulation. Crit Care 26, 103 (2022).

Is volume leak index (VLI) a marker of severity of illness in sepsis?

Study to test if volume leak index (VLI) is a marker of severity of illness in sepsis.

• Sepsis is an important cause of morbidity and mortality.
• Capillary leak, the escape of protein-rich fluid leaks out of vessels into organs, is an important part of sepsis.
• VLI can be estimated by the change in hematocrit after IV fluids.
• Changes in hematocrit would be inversely proportional to the degree of capillary leak.

Null hypothesis

Septic patients with a high VLI will have the same risk for morbidity and mortality as patients with a low VLI.

Cohort

Patients w/ sepsis (eICU, MIMIC, Amsterdam, SNUH).

Exposure

VLI (quartiles of severity and continous variable).

Outcome

In-hospital mortality and 36-84 fluid balance.

Model

Generalized Additive Model