🧪 Tri-Modal Antifungal Catheter Lock (TCL) — Proof of Invention Record
Version: v1.0.0
Release date: 12 November 2025
📘 Summary
This release contains the complete, timestamped disclosure package for the Tri-Modal Antifungal Catheter Lock (TCL) —
a novel non-systemic antimicrobial lock composition designed to eradicate Candidozyma (Candida) auris and other resistant fungal biofilms within indwelling medical devices.
The TCL formulation integrates three coordinated mechanisms:
| Component | Target | Function |
|---|---|---|
| Echinocandin (micafungin) | β-glucan synthase | Inhibits fungal cell-wall synthesis |
| β-1,3-Glucanase | Extracellular matrix | Liquefies β-glucan biofilm polymers |
| Ga³⁺ + EDTA complex | Metal metabolism | Replaces Fe³⁺ and disrupts iron homeostasis |
These effects combine to produce a ≥3-log CFU reduction within 90 min, with no observed catheter degradation.
🔬 Mechanistic Model
🔬 Mechanistic Parameters
- ηₑ꜀ₕ — Echinocandin inhibition efficiency
- ηₑₙ𝓏 — Enzymatic matrix-digestion efficiency
- [Fe³⁺]₍biofilm₎ / [Fe³⁺]₀ — Normalized iron availability after Ga³⁺ substitution
Concurrent action of all three terms drives superlinear collapse of fungal viability.
🧩 Included Files
| Path | Description |
|---|---|
paper/TCL_Proof_of_Invention.pdf |
Compiled disclosure PDF |
figures/ |
TikZ schematics (TCL overview, Cas12 workflow) |
data/ |
Placeholder for supporting datasets |
.zenodo.json / CITATION.cff |
DOI + citation metadata |
LICENSES/CC-BY-NC-4.0.txt |
Non-commercial license terms |
📜 Citation
Valamontes, A., & Adamopoulos, I. (2025).
Tri-Modal Antifungal Catheter Lock (TCL): Proof of Invention Record (v1.0.0).
Kapodistrian Academy of Science.
Zenodo. https://doi.org/10.5281/zenodo.17589267
📫 Contact & Licensing
Inventor: Antonios Valamontes
Affiliation: Kapodistrian Academy of Science
Email: [email protected]
Commercial manufacturing or distribution of TCL formulations requires prior written authorization.
For licensing inquiries, contact the address above.
Witnessed by:
Dr. Ioannis Adamopoulos — Public Health and Environmental Inspector,
Department of Environmental Hygiene and Public Health Inspections, Region of Attica, Hellenic Republic.
🔖 License
Documentation, figures, and LaTeX sources are released under
Creative Commons Attribution–NonCommercial 4.0 International (CC BY-NC 4.0)
https://creativecommons.org/licenses/by-nc/4.0/
🧾 Checksums (optional but recommended)
🧠 Keywords
Candida auris • biofilm • catheter lock • echinocandin • β-1,3-glucanase • gallium • EDTA • infection control • public health
Full Changelog: https://github.com/Galactic-Code-Developers/Tri-Modal-Catheter-Lock-TCL/commits/TCLv1.0